Proteomics

Funded By:

National Science Engineering Research Council (NSERC) Discovery and IRC, ISTP Canada, Canadian Institute for Health Research (CIHR), Canadian Cancer Society Research Institute (CCSRI), Canadian Foundation for Innovation (CFI), Ontario Innovation Trust (OIT), Ontario Research and Development Challenge Fund (ORDCF), Genome Canada, National Research Council (NRC), Ontario Cancer Biomarker Network (OCBN), AB Sciex, and Sanofi Pasteur industrial partners among many other agencies.

Research:

The focus of the proteomics section of the CRMS is the development and application of new tools for the identification and quantification of ensemble of proteins. Projects include shotgun organellar proteomics of Tetrahymena thermophila and the investigation of myogenesis-related proteins and their posttranslational modifications. Another important aspect of our research is the discovery of cancer biomarkers, as well as their identification, verification, and quantification in endometrial, brain, head-and-neck, ovarian, and kidney cancer. Current and former collaborators include Drs. Dasantila Golemi-Kotra, Ronald E. Pearlman and John C. McDermott (York University); Ranju Ralhan, Terence J. Colgan, Christina M. MacMillan, Ian J. Witterick, and Iona Leong (Mount Sinai Hospital); Alexander D. Romaschin and George M. Yousef (St. Michael’s Hospital); Abhijit Guha and Gelareh Zadeh (Hospital for Sick Children and Toronto Western Hospital); and Kenneth R. Evans and Terrence Sills (Ontario Cancer Biomarker Network).

 

The facility has a suite of mass spectrometric instruments and new instruments are periodically acquired to ensure that the facility remains state-of-the-art. The combination of instruments and expertise that the facility can access permits us to undertake research projects that require a great deal of analytical flexibility and expertise.